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Poster (Scientific congresses and symposiums)
Comparing the qualitative performances of handheld NIR and Raman spectrometers for the analysis of falsified pharmaceutical products.
Ciza Hamuli, Patient; Waffo Tchounga, Christelle; Coic, Laureen et al.
201811th International Symposium on Drug Analysis and the 29th International Symposium on Pharmaceutical and Biomedical Analysis.
 

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Keywords :
NIR spectroscopy; Raman spectroscopy; Clustering algorithm; DD-SIMCA; PLS-DA
Abstract :
[en] The last decade has seen a significant growth of the pharmaceutical market of emerging countries to the point that it has induced many falsifications. Research activities have followed this growth but not proportionately. Recently, several chemical analysis methods for the detection of counterfeit or falsified drugs have been developed using spectroscopic techniques. In this study, different spectrometers were used to collect near-infrared (NIR) and Raman spectral data sets of selected drugs to help improve existing methods. The objective of this work was to evaluate the qualitative performances of the NIR and Raman spectrometers; two benchtop equipment (NIR and Raman) and four handheld ones (three Raman and one NIR) were used. In particular, we made a critical comparison in the evaluation of the accuracy of the prediction. The predictive ability of the different equipments was compared statistically using chemometrics: clustering algorithm, soft modeling (DD-SIMCA) and hard modeling (PLS-DA). All these chemometric strategies were applied on each equipment. Clustering approaches, DD-SIMCA and PLSDA enabled us to compare the qualitative performances of handheld NIR and Raman equipment and to make a critical analysis of their use in the field of the detection of falsified drugs.
Research center :
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Ciza Hamuli, Patient  ;  Université de Liège - ULiège > Doct. sc. bioméd. & pharma. (paysage)
Waffo Tchounga, Christelle  ;  Université de Liège - ULiège > stage conv. étrangères ou CFB en médecine
Coic, Laureen  ;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Mbinze Kindenge, Jérémie;  Université de Kinshasa > pharmacie galénique et analyse des médicament > analyse des médicaments
Ngono, Rose;  University of YaoundéI > Faculty of Medicine and Biomedical Sciences and National Drug > Control and Valuation (LANACOME)
Marini Djang'Eing'A, Roland ;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Hubert, Philippe  ;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Sacre, Pierre-Yves  ;  Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Ziemons, Eric  ;  Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Language :
English
Title :
Comparing the qualitative performances of handheld NIR and Raman spectrometers for the analysis of falsified pharmaceutical products.
Alternative titles :
[fr] Comparaison des performances qualitatives des spectromètres PIR et Raman portables pour l'analyse de produits pharmaceutiques falsifiés.
Publication date :
September 2018
Number of pages :
2x1m
Event name :
11th International Symposium on Drug Analysis and the 29th International Symposium on Pharmaceutical and Biomedical Analysis.
Event organizer :
the International Symposium DA-PBA 2018
Event place :
Louvain, Belgium
Event date :
du 09 Septembre au 12 Septembre 2018
Audience :
International
Name of the research project :
création d'un centre d'excellence en Assurance et Contrôle de Qualité des médicaments et produits de santé
Funders :
ARES - Académie de Recherche et d'Enseignement Supérieur [BE]
Service public de Wallonie : Direction générale opérationnelle de l'économie, de l'emploi et de la recherche - DG06
Commentary :
Projets de Formation sud
Available on ORBi :
since 20 July 2018

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